Category: Hydroxychloroquine

Doctor’s Advice on Early Treatment for COVID-19

Every viral illness starts that way. The more it’s allowed to progress, the more it takes over the cells and replicates itself. That’s why this virus absolutely had to be treated early to prevent those damages. Primarily what has killed people with COVID is a delay to treatment, and allowing the exaggerating inflammatory response and blood clotting response to take hold in the body.

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The Chloroquine Wars Part XIV – How to Rig Research: Surgisphere Part I

It was in these very moments in late May when public health officials lost all credibility—a credibility that cannot be restored without major changes taking place. Despite most evidence pointing to a likelihood of HCQ efficacy, they made their call on the back of data supposedly tucked away in a database that nobody had verified, declared it definitive, then swiftly pushed for policy changes around the world.

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Hyperglycemia, hydroxychloroquine and the COVID‐19 pandemic

Hydroxychloroquine also can act as an oral hypoglycemic agent, as patients with diabetes taking hydroxychloroquine for rheumatologic diseases had a significant reduction in hemoglobin A1c when compared to methotrexate,40 and thus can serve to reduce hyperglycemia, a possible COVID‐19 risk factor for disease severity.

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The Chloroquine Wars Part XIII -A Clockwork Orange Man

Immediately following HCQ’s Trump moment, the media went on an all-out blitz to associate the topic of HCQ with a sense of fear. Fear of Trump, fear of death, fear of incompetence, fear of opposing scientific authorities, fear of using medicine needed by somebody else, and fear of the unknown. And the campaign of fear didn’t stop there.

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Clinical outcomes of patients with mild COVID-19 following treatment with hydroxychloroquine in an outpatient setting

Our investigation of a large national cohort appears to support early administration (within the first 3 to 7 days of COVID-19 diagnosis) of HCQ in mild COVID-19 disease in an outpatient setting for reducing hospitalizations and deaths without any serious adverse HCQ-related effects.
If this finding is confirmed in future clinical trials, HCQ as a cheap and available drug may still play a role in a specific population with respect to reducing COVID-19 burden, particularly in resource-poor countries.

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Hydroxychloroquine or Ivermectin? The Netherlands’ Nonsense Beats Australia’s !!!

Did the Netherlands work out that early outpatient treatment using hydroxychloroquine, ivermectin & other drugs, hospitalisations can reduce by 80% or more?
It would take just a few weeks to bring down new hospitalizations for COVID-19 to around 40 per day in the country, if general practitioners were authorized to treat the disease early, using a range of early treatment medications, including those now exposing doctors to penalties of up to 150,000 euros!

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Association of Italian Doctors successfully treats COVID patients with vitamin D and hydroxychloroquine

From an ingenious intuition of the founder, Mauro Rango, an Italian living in the Mauritius Islands. There, the Coronavirus was quickly eradicated in the beginning, with drugs that we have known for decades, such as Azithromycin, Hydroxychloroquine or Cortisone, while in Italy people died like flies. How was it possible that in Africa, where health care is not as advanced as in Italy, such marvellous results were achieved, while in Italy the spread of the disease could not be contained?

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Timing and dosing are the key to HCQ + AZ treatment in elderly Covid-19 patients

Antiviral therapy is only of interest during the early and intermediate viral phase when the virus is present and replicates, and is of no use during the late inflammatory phase (cytokine storm). Most therapeutic trials, unfortunately, have been carried out in hospitalized patients, which is to say probably often too late, because the patients are in the early inflammatory phase.

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The Chloroquine Wars Part VI – The Simple Logic of the Hydroxychloroquine Hypothesis

The Hydroxychloroquine Hypothesis: That there is some appropriate dosage of hydroxychloroquine, alone or in some combination with other medication, that successfully prevents some COVID-19 cases (PrEP/PEP) or treats some COVID-19 sufferers (Early/Late/Critical).
Remaining entirely unblemished after a year of trials and observations, the current evidence in favor of the Primary HCQ Hypothesis fully validates the HCQ Hypothesis. The logic is so simple that it almost feels like your livelihood would have to be on the line to deny it.

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Structural basis of anti-SARS-CoV-2 activity of hydroxychloroquine: specific binding to NTD/CTD and disruption of LLPS of N protein

In this study, by use of DIC microscopy and NMR spectroscopy, for the first time we have decoded that HCQ specifically binds to both N-terminal domain (NTD) and C-terminal domain (CTD) of SARS-CoV-2 nucleocapsid (N) protein to inhibit their interactions with nucleic acids (NAs), as well as to disrupt its NA-induced liquid-liquid phase separation (LLPS) essential for the viral life cycle including the package of gRNA and N protein into new virions.

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The Chloroquine Wars Part IV

Why then does the pharmaceutical industry and its promoters insist on conducting RCTs before something is accepted as true? RCTs take substantial amounts of time and significant resources to conduct. This creates a barrier to entry, especially for inexpensive solutions to medical problems. In other words, the myth that RCTs are some necessary “gold standard” is a deception that, along with regulatory agency, prevent any possibility for simpler and less expensive (less profitable) medical solutions to gain traction.

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We learn that 30 million Indians have been cured by ivermectin and hydroxychloroquine, but donkeys everywhere, like Véran or Wargon, claim that there is no cure…

India has conquered the disease with hydroxychloroquine and ivermectin, uses a traditional vaccine, exports experimental vaccines for these idiotic Westerners … There are 1,230 deaths per million inhabitants over 65 (six times less than in France). If we had listened to Raoult and followed the Indian model, today we would have 500 cases of covid per day and 75,000 fewer deaths …

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The Chloroquine Wars Part III

If the argument rests on “RCTs as the gold standard”, there is little doubt that the evidence dramatically favors using HCQ as a standard early stage therapeutic! But it is reasonable to assess the quality of all the evidence to reach beyond gold for the ultimate and supreme standards of scientific evidence. That too we plan to present in future articles.

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Professor Risch Responds to Dr Rushworth over Hydroxychloroquine Post

“As a clinician, you should know that Covid-19 outpatient disease is viral replication, vs hospitalized disease which is florid pneumonia. These are absolutely different conditions and studies of the treatment of one cannot be extrapolated to the treatment of the other.
This massive body of evidence, summarized by the Cochrane Library, demonstrates that well-conducted hydroxychloroquine observational studies on average, produce very similar associations as the corresponding RCTs.

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The Chloroquine Wars Part II

On face, it certainly appears that complete silence in the public sphere about hydroxychloroquine’s potential was coordinated by powerful media forces.

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The Chloroquine Wars: Part I

A famous infectious diseases specialist from France, Dr. Didier Raoult, devised treatments for the bacterial infections that cause Q fever and Whipple’s disease. If all that weren’t enough, hydroxychloroquine has anti-thrombotic properties, meaning it reduces blood clotting for patients suffering excessive clotting. It even inhibits autophagy (cellular self-destruction) setting up hydroxychloroquine for research as a unique cancer medication. No other medicine discovered, isolated, or engineered does all of these things. Most importantly during the recent pandemic, hydroxychloroquine, like quinine, also demonstrates antiviral activity. In short, hydroxychloroquine is a gift from nature—one of the most broadly effective and repurposed drugs in the history of medicine. Billions of doses of hydroxychloroquine are distributed annually, and the WHO includes it in its list of essential medicines.

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