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Source: statnews The World Health Organization is resuming a clinical trial exploring whether the malaria drug hydroxychloroquine can effectively treat Covid-19, after pausing enrollment in the study to review safety concerns about the drug. The hydroxychloroquine investigation is just one arm of the agency’s Solidarity Trial, which is testing different therapies to determine which are beneficial […]
Source: The Lancet Expression of concern: Hydroxychloroquine or chloroquinewith or without a macrolide for treatment of COVID-19:a multinational registry analysis. Important scientific questions have been raised aboutdata reported in the paper by Mandeep Mehra et al—Hydroxychloroquine or chloroquine with or without amacrolide for treatment of COVID-19: a multinationalregistry analysis (1) – published in The Lancet […]
Source: Science the Wire If you’re following at all the search for COVID-19 treatments, and possibly even if not, you will have seen the flurry of media coverage for the observational study in The Lancet, ‘Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis’. It made the news not least […]
Hydroxychloroquine alone is not the whole story. It needs to be combined with azithromycin and zinc.
Source: Hindustan Times The results of the study are based on a case control study for which participants were randomly drawn from the countrywide Covid-19 testing data portal maintained by ICMR. As many as 80% of the health care workers (HCWs) on six or more prophylactic doses of the anti-malarial drug hydroxychloroquine (HCQ) were not […]
Source: Preprints.org The challenge regarding COVID-19 is to prevent complications and fatal evolution. Azithromycin (AZM) and hydroxychloroquine (HCQ) have proven their antiviral effect in vitro. We aimed to assess the efficacy and safety of AZM alone or combined to HCQ, prescribed, at an early stage, in patients with Covid-19, in a primary care setting. Eighty-eight […]
Source: France Soir Surgisphere is the company responsible for collecting data from Professor Mehra’s study, which has received worldwide attention for the past 7 days. After our first interview with Mr Mehra who had left us skeptical about the form and content, we became interested in this business. And there some questions arise and surprises. The surgisphere company has: Several addresses that are […]
Source: Medicine Uncensored by James M Todaro, MD (Columbia MD, @JamesTodaroMD)May 29, 2020, (updated May 30, 2020) Misinformation is bad. Misinformation in medicine is worse. Misinformation from a prestigious medical journal is the worst. Herein is a detailed look at the controversial Lancet study that resulted in the World Health Organization ending worldwide clinical trials on hydroxychloroquine in order […]
Source: Brasil Sem Medo Study that rejects hydroxychloroquine use in Covid-19 patients is not science, but instrumentalization of science. The twilight of quinine A study published in the prestigious scientific journal The Lancet , on the 22nd, seemed to definitely change the direction of the public debate on the use of chloroquine and hydroxychloroquine in the treatment […]
Source: Zeekannada New Delhi [India], May 29 (ANI): After the Union Health Ministry expressed reservations about the World Health Organisation’s (WHO) advisory to suspend hydroxychloroquine (HCQ) usage in treating COVID-19 patients, now, India’s nodal government agency ICMR (Indian Council of Medical Research) overseeing the country’s response to the coronavirus pandemic has also written to the […]
Source: The Guardian Australian researchers query origin of data used for Lancet study. Questions have been raised by Australian infectious disease researchers about a study published in the Lancet which prompted the World Health Organization to halt global trials of the drug hydroxychloroquine to treat Covid-19. The study published on Friday found Covid-19 patients who received the malaria drug […]
Source: El Pais The Medicines Agency considers that the conclusions of the study that alerted about the drug are not “solid enough”. The Spanish Agency for Medicines and Health Products (AEMPS) considers that the recent study published in The Lancet that warned about the risks of hydroxychloroquine against the coronavirus does not provide conclusions “sufficiently strong” to stop […]
Source: Argus Leader South Dakota’s study of an antimalarial drug’s impact on the coronavirus can’t be compared to other studies halted, a Sanford Health leader said. Other hydroxychloroquine clinical trials have involved different patients and dosages than South Dakota’s study, said Allison Suttle, chief medical officer at Sanford Health. Suttle said the study in South Dakota hasn’t […]
Source: Medrxiv View ORCID Profile Amanda Chamieh, Claude Afif, View ORCID Profile Gerard El-Hajj, View ORCID Profile Omar Zmerli, Isabelle Djaffar-Jureidini,View ORCID Profile Roy A. Raad, Raja Ashou, George Juvelekian,View ORCID Profile Jean-Marc Rolain,View ORCID Profile Eid Azar doi: https://doi.org/10.1101/2020.05.28.20114835 This article is a preprint and has not been certified by peer review [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used […]
Source: Mediterranee Infection COVID-IHU #15 Version 1 du 27 Mai 2020Early diagnosis and management of COVID-19 patients: a real-life cohort study of 3,737 patients, Marseille, France Abstract Background:In our institute in Marseille, France, we proposed early and massive screening for coronavirus disease 2019 (COVID-19). Hospitalization and early treatment with hydroxychloroquine and azithromycin (HCQ-AZ) was proposed for the positive cases. Methods:We retrospectively report the clinical […]
Source: Le Devoir Canada Following the publication of the results of a large study indicating that administration of chloroquine or hydroxychloroquine alone or in combination with azithromycin to patients with COVID-19 who were hospitalized provided no benefit in the treatment of COVID-19, and even increased the risk of cardiac arrhythmia and mortality, the World Health […]
Source: Zendo In an open letter to MR Mehra, SS Desai, F Ruschitzka, and AN Patel, authors of “Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis”. Lancet. 2020 May 22:S0140-6736(20)31180-6. doi: 10.1016/S0140-6736(20)31180-6. PMID: 32450107, and to Richard Horton (editor of The Lancet): Concerns regarding the statistical analysis […]
Source: Oxford Academic – American Journal of Endimology Original unedited manuscript as PDF Abstract More than 1.6 million Americans have been infected with SARS-CoV-2 and >10 times that number carry antibodies to it. High-risk patients presenting with progressing symptomatic disease have only hospitalization treatment with its high mortality. An outpatient treatment that prevents hospitalization is […]
Source: Global Research A few years ago the British medical journal, The Lancet, published a paper touting the safety of HCQ. But this was before HCQ with zinc was found effective if used earlier enough against Covid-19. Covid-19 turned HCQ’s effectiveness into a big problem for Big Pharma’s big profits. The solution was another study by medical […]
Source: Mediterranee Infection Why this discrepancy between the preprint version and the version published in the BMJ? Tang et al. – Data (text and figures) evidencing a favorable effect of HCQ removed in the final published version (version 2 on MedRxiv and final version on BMJ) Version 1: https://www.medrxiv.org/content/10.1101/2020.04.10.20060558v1?versioned=true Version 2: https://www.medrxiv.org/content/10.1101/2020.04.10.20060558v2 BMJ Final: https://www.bmj.com/content/369/bmj.m1849
Source: Within Nigeria The National Agency for Food and Drug Administration and Control (NAFDAC) says it will continue hydroxychloroquine clinical trials for COVID-19 treatment despite the suspension of the drug test by the World Health Organisation (WHO). This was made known by NAFDAC Director-General, Mojisola Adeyeye, who stated that such will be concluded within four months. She […]
Source: Conexaopolitica Brazilian scientists and academics have written an open letter on the “science” of the coronavirus pandemic. The coordinator of the statement is Marcos Nogueira Eberlin. He is a member of the Brazilian Academy of Sciences and holds a PhD in chemistry from the University of Campinas. After postdoctoral work at Purdue, he founded […]
Source: Recovery Trial Professor Peter Horby, Professor Martin LandrayRECOVERY trial Co-chairsNuffield Department of Public HealthOxford24th May 2020 Dear Peter and Martin RECOVERY trial DMC Chairman’s reportIn the light of the response by MHRA to my letter, I arranged an urgent re- review by the full committee of the safety and efficacy data that were available […]
Source: US News THOUSANDS OF BRITISH health care workers will participate in a global trial to test the efficacy of a drug that US President Trump recently disclosed he has been taking as a preventative measure against the coronavirus. The Mahidol Oxford Tropical Medicine Research Unit said Thursday that 40,000 front-line workers and staff in Europe, […]
Source: Washington Times A forthcoming Australian scientific study concludes that the coronavirus causing the global pandemic contains unique properties suggesting it was manipulated in a Chinese laboratory and was not the result of a natural occurrence. Five scientists who conducted the study discovered an unusual ability of the SARS-CoV-2 virus, as the pathogen behind COVID-19 […]
Source: FOX 2 – Detroit The FDA has warned against taking hydroxychloroquine, but President Trump says he’s taking it and isn’t concerned. Dr. William O’Neill, a world-renowned Henry Ford doctor, is leading one of the largest U.S. studies into the drug. He gives us a little more information. “The drug has been available for decades. Initially, it […]
Source: SagePub.com Convalescent blood products are promising potential therapies for COVID-19. Other antivirals such as chloroquine or HCQ, remdesivir, and immune modulators such as tocilizumab are the other potential therapies for COVID-19 that are being tested in clinical trials. The use of antiretrovirals, such as lopinavir/ritonavir, did not provide any benefit in a RCT. Steroids […]
SOURCE: Covexit.com The esteemed professor Paolo Zanotto, from the University of Sao Paulo, has released a list of 50 scientific references supporting the use of hydroxychloroquine for COVID-19. Professor Paolo Zanotto studied virology at University of Oxford and is a Microbiology Professor at Universidade de São Paulo. He has published extensively, including in prestigious journals […]
Source: Full Measure If you’ve watched the news lately, you might be under the impression that a medicine President Trump touted as a possible game changer against coronavirus— has been debunked and discredited. Two divergent views of the drug, hydroxychloroquine, have emerged: the negative one widely reported in the press and another side you’ve probably […]
Source: MedRxiv Background: No consensus or evidence-based guideline currently exists for pharmacological therapy against Coronavirus Disease 2019 (COVID 19). While South Korea has been relatively successful in managing the pandemic, its management of confirmed cases and treatment outcomes have not been reported to date. Methods: A retrospective cohort study of the 358 laboratory-confirmed SARS CoV […]
Source: NY1 NEW YORK – Researchers at NYU’s Grossman School of Medicine found patients given the antimalarial drug hydroxychloroquine along with zinc sulphate and the antibiotic azithromycin were 44 percent less likely to die from the coronavirus. “Certainly we have very limited options as far as what we have seen work for this infection so […]
Source: Springer Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high fatality. The most urgent need is to find effective treatments. We sought to determine whether hydroxychloroquine (HCQ) application may reduce the death risk of critically ill COVID-19 patients. In this retrospective study, we included 550 critically ill COVID-19 patients who […]
Source: Renascenca The Director-General of Health stresses that national and international institutions continue to monitor the “evolution of the use of this medicine worldwide and are adjusting their recommendations accordingly.” The director-general of Health, Graça Freitas, says that in Portugal there is no record of adverse reactions to the drug hydroxychloroquine, which can be used […]
Source: Genetic Engineering & Biotechnology News The lack of treatment options for COVID-19 patients, potential promise in repurposing drugs, and controversy surrounding the anti-malarial drug hydroxychloroquine have created a storm of questions about the drug’s efficacy that the National Institute of Allergy and Infectious Diseases (NIAID) is ready to answer. To do that, the organization […]
Source: Bloomberg Scientists from the University of Oxford are starting a first-of-its-kind study to see whether available drugs can help keep older, more vulnerable people with mild cases of Covid-19 from becoming severely ill. More than 500 U.K. doctors’ offices are recruiting for the trial of drugs that are already approved for other purposes, such […]
Source: Fox News TAMPA, Fla. – Frontline healthcare workers in Tampa are participating in a clinical trial to see if a drug being used to treat COVID-19 can actually prevent the virus. It is part of a nationwide research program by HERO (Healthcare Worker Exposure Response and Outcomes) on hydroxychloroquine, an FDA-approved drug commonly used to treat malaria. “Does this hydroxychloroquine […]
Source: MedRxiv Repurposed drugs that are immediately available and have a good safety profile constitute a first line of defence against new viral infections. Despite a limited antiviral activity against SARS-CoV-2, several drugs serve as candidates for application, not only in infected individuals but also as prophylaxis to prevent infection establishment. Here we use a […]
Source: Preprints Although no specific treatment for COVID 19 has been proven effective yet, some drugs with in vitro potential against SARS-CoV-2 virus have been proposed for clinical use. Hydroxychloroquine has in vitro anti-viral and immunomodulatory activity, but there is no current clinical evidence of its effectiveness on the outcome of the disease. Methods: We enrolled all […]
Source: MedRxiv Background: COVID-19 has rapidly emerged as a pandemic infection that has caused significant mortality and economic losses. Potential therapies and means of prophylaxis against COVID-19 are urgently needed to combat this novel infection. As a result of in vitro evidence suggesting zinc sulfate may be efficacious against COVID-19, our hospitals began using zinc […]
Source: The Australian The researchers leading a major Australian clinical trial into whether the drug hydroxychloroquine is effective in treating coronavirus have addressed concerns over whether they should be administering the drug, critiquing two international studies. The trial involves more than 70 hospitals nationwide and will test the efficacy of hydroxychloroquine in preventing severe disease […]