Source: Full Measure

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If you’ve watched the news lately, you might be under the impression that a medicine President Trump touted as a possible game changer against coronavirus— has been debunked and discredited. Two divergent views of the drug, hydroxychloroquine, have emerged: the negative one widely reported in the press and another side you’ve probably heard less about. Never has a discussion about choices of medicine been so laced with political overtones. Today, how politics, money and medicine intersect with coronavirus.

Sharyl: Camps largely divided along political lines. Many right-leaning media figures sided with hydroxychloroquine while the left-leaning press backed remdesivir. Each accusing the other of ignoring real science.

Dr. William O’Neill: I’ve never seen science politicized in 40 years of practice.

Sharyl: Cardiologist Dr. William O’Neill is a medical director at the Henry Ford Health System in Detroit, Michigan where they’re studying both remdesivir and hydroxychloroquine.

Some people in the media are treating hydroxychloroquine as if it’s something that’s being pitched by charlatans, it’s dangerous, and that’s been debunked and discredited. What do you make of that?

Dr. O’Neill: I think that’s very harmful. President Trump touted it early and so then the media set out to disprove and discredit it without any regard for science. I think those of us that are actually involved in the scientific endeavor feel that there is some value to it and it has to be tested.

Sharyl: Dr. O’Neill says he’s prescribed hydroxychloroquine to help numerous coronavirus patients and saw improvement in all of them. He’s less impressed, so far, by remdesivir.

Dr. O’Neill: There’s a lot of hype for the drug. I saw the original new England Journal article study and I saw the Lancet study and to me it’s just like a big Ho Hum. I just don’t see a big benefit to it.

Dr. O’Neill is now leading a study to find out if hydroxychloroquine can serve a critical role as a medicine to prevent coronavirus. But he says the bad press is making it difficult.

Dr. O’Neill: Now people are scared to use the drug without any scientifically valid concern. We’ve talked with our colleagues at the University of Minnesota who are doing a similar study, and at the University of Washington. We’ve treated 400 patients and haven’t seen a single adverse event. And what’s happening is because of this fake news and fake science, the true scientific efforts are being harmed because people now are so worried that they don’t want to enroll in the trials.

Dr. Steven Hatfill: Why are the press running medicine in the United States? This is not right.

Sharyl: Dr. Steven Hatfill is a biomedical scientist who worked on Ebola and studies pandemic responses and medicine. He says there’s an unwarranted campaign against hydroxychloroquine.

Sharyl: You think lives were lost because it wasn’t used?

Dr. Hatfill: Yes, lives were lost.

He took hydroxychloroquine years ago for malaria and recently, again, to test to prevent coronavirus.

Sharyl: A preventive would mean, if it were to work, that the fear that this comes back before there’s a working vaccine, the fear that we have another shutdown …

Dr. Hatfill: a return to work … early detection, return to work. Would I give it as a prophylaxis to everybody? No. But for fit, healthy, critical workers going back to work or high risk populations; chronic obstructive pulmonary disease, ex-smokers, diabetics, obesity …

Sharyl: Might work for them?

Dr. Hatfill: It might work for them.

Sharyl: A third scientist we spoke to, who says hydroxychloroquine has been unfairly disparaged, is Dr. Jane Orient, head of the Association of American Physicians and Surgeons.

How do you account for the difference in medical and scientific opinion about this drug? Because some people seem so certain that it can be a positive benefit to coronavirus patients, maybe even crucial in the early days, whereas some people are convinced it should absolutely not be used.

Dr. Orient: That’s a very good question. But the ones who have the most experience are very enthusiastic about the possibilities. And we do have naysayers that we suspect may have a little conflict of interest because they are so enthusiastic about remdesivir, which is a new drug that hasn’t been approved for anything. And that so far is showing a really very equivocal or even negative results.

Sharyl: All three scientists criticized that VA report casting doubt on hydroxychloroquine as little more than a list of cases with crucial details missing. It turns out one author of the report received research funding from Gilead, the maker of remdesivir, including a 247-thousand dollar grant in 2018.

Orient: I think we have to look at the money. There’s no big profits made in hydroxychloroquine. It’s very cheap, easy to manufacture, been around for 70 years. It’s generic. Remdesivir is a new drug that could be very expensive and very lucrative if it’s ever approved. So I think we really do have to consider there’s some financial interest involved here.

Dr. Hatfill: Some of these decisions did not seem to be rational.

And when things, in my opinion that are so clear, the right path to take aren’t taken, very often: Money is somehow involved.

Sharyl: When it comes to money, we checked financial ties among experts on the government panel devising coronavirus treatment guidelines— which had the effect of dialing back hydroxychloroquine use and giving an edge to remdesivir.

We found that of 11 members reporting links to a drug company, nine of them named relationships to remdesivir’s maker Gilead. Seven more, including two of the committee’s leaders, have ties to Gilead beyond the 11 months they had to disclose. Two were on Gilead’s advisory board. Others were paid consultants or received research support and honoraria. Nobody reported ties to hydroxychloroquine which is now made by numerous generic manufacturers and is so cheap, analysts say even a spike in sales would not be a financial driver for the companies.

In the end, politics and money aside, at least some scientists aren’t ready to count hydroxychloroquine out of the coronavirus equation. Even if others already have.

Read the original article here: http://fullmeasure.news/news/cover-story/hydroxychloroquine

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