Chronic treatment with hydroxychloroquine and SARS-CoV-2 infection.
29/06/2020 No Comments
Our data suggest that chronic treatment with HCQ confer protection against SARS-CoV-2 infection.
Our data suggest that chronic treatment with HCQ confer protection against SARS-CoV-2 infection.
No life-threatening modifications of the QT interval was observed in non-severe COVID-19 patients treated ambulatory with hydroxychloroquine and azithromycin. Studies are needed in critical-ill and older patients.
The clinical trials on this list are studying Hydroxychloroquine. All trials on the list are supported by NCI.
This study provides evidence that (hydroxy)chloroquine may be used effectively in treating moderate COVID-19 and supports larger trials.
Conclusions: In subjects free of COVID-19, we found a small increase in QTc associated with use of chloroquine, but not hydroxychloroquine. We found no increased mortality associated with use of hydroxychloroquine.
This study provides evidence that (hydroxy)chloroquine may be used effectively in treating moderate COVID-19 and supports larger trials.
Significantly higher rates of discharge home were observed in patients treated by HCQ, a novel finding warranting further confirmation in replicative studies.
How can we trust the established authorities or prestigious journals when, in this perilous time, trials of an available, inexpensive, long-established drug appear to be designed to fail, while risking the lives of their subjects through deliberate or negligent drug overdoses?
It is not affected by the FDA’s decision today, and there is no evidence that the use of hydroxychloroquine as a potential prophylaxis presents a health risk in that setting.
None of the patients died in the studied period and only 6 have to be admitted in conventional hospitalization area.
Source: MedRxiv Abstract Background: While several trials are ongoing for treatment of COVID-19, scientific research on chemoprophylaxis is still lacking even though it has potential
Source: Hindustan Times The results of the study are based on a case control study for which participants were randomly drawn from the countrywide Covid-19
Source: El Pais The Medicines Agency considers that the conclusions of the study that alerted about the drug are not “solid enough”. The Spanish Agency
SOURCE: Covexit.com The esteemed professor Paolo Zanotto, from the University of Sao Paulo, has released a list of 50 scientific references supporting the use of
Source: Bloomberg Scientists from the University of Oxford are starting a first-of-its-kind study to see whether available drugs can help keep older, more vulnerable people
Source: Fox News TAMPA, Fla. – Frontline healthcare workers in Tampa are participating in a clinical trial to see if a drug being used to treat COVID-19 can actually
Source: MedRxiv Repurposed drugs that are immediately available and have a good safety profile constitute a first line of defence against new viral infections. Despite
Source: Preprints Although no specific treatment for COVID 19 has been proven effective yet, some drugs with in vitro potential against SARS-CoV-2 virus have been
Source: MedRxiv Background: COVID-19 has rapidly emerged as a pandemic infection that has caused significant mortality and economic losses. Potential therapies and means of prophylaxis
Source: MedRxiv Background Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In
Source: MedRxiv This study provides the first in vivo evidence that zinc sulfate in combination with hydroxychloroquine may play a role in therapeutic management for
Source: India Today As some Western studies found hydroxychloroquine ineffective as a potential Covid-19 therapy, a new Chinese research has reported that the anti-malarial drug
Dr. Zelenko, during his interview with Steve Bannon, said his protocol provides a 95% reduction in death, that France used a similar protocol and had an 88% reduction in death.
Source: MedRxiv Importance: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high mortality. The most urgent thing is to find effective
Source: 7News Sunrise Clive Palmer has purchased 32,900,000 doses of hydroxychloroquine, and donated the supply to the National Medical Stockpile. The controversial businessman believes the
This study focuses on anti-malarial drugs like hydroxychloroquine, which have been seen as the most used treatment for COVID-19
The benefits of hydroxychloroquine being investigated in multi-site clinical trial launching in April Researchers are investigating whether hydroxychloroquine – a commonly used anti-malarial and autoimmune
Data from week two of largest ongoing international market research study on COVID-19 New York, New York – April 8, 2020 – Week two data of the
On March 19, we published a story about a trial study conducted by French researchers which showed a combination of Hydroxychloroquine (brand name Plaquenil) and Azithromycin to be effective
To increase the effectiveness of treatments and results, researchers need to give greater focus, when designing trials and when extrapolating from them.
Doctors of subordinate Moscow medical institutions are invited to participate in the study of the drug for the prevention of COVID-19. A medicine called hydroxychloroquine is
Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious diseases.
Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer.
Here, we summarize the results or design of clinical studies recently completed or initiated to evaluate the therapeutic activity of chloroquine derivatives in cancer patients.
HCQ reduces lipopolysaccharide/TLR-mediated immune activation; this compound could be a useful immunomodulant in HIV-infected patients.
The anti-HIV effect of chloroquine/hydroxychloroquine is modest by itself but is additive or synergistic when combined with selected antiretrovirals.