Medical Study Archives

Structural basis of anti-SARS-CoV-2 activity of hydroxychloroquine: specific binding to NTD/CTD and disruption of LLPS of N protein

17/03/2021 No Comments

In this study, by use of DIC microscopy and NMR spectroscopy, for the first time we have decoded that HCQ specifically binds to both N-terminal domain (NTD) and C-terminal domain (CTD) of SARS-CoV-2 nucleocapsid (N) protein to inhibit their interactions with nucleic acids (NAs), as well as to disrupt its NA-induced liquid-liquid phase separation (LLPS) essential for the viral life cycle including the package of gRNA and N protein into new virions.

The Chloroquine Wars Part V – A Closer Look at RCTs Studying Hydroxychloroquine Efficacy

14/03/2021 No Comments

This is now one of the most well-studied treatments in the history of medicine, and the evidence is overwhelming. The chance that these results could occur at random is approximately 1 in 208 quadrillion. That is, p = 0.000000000000048. Having read a few thousand research papers, I have never before seen a p-value this low in the testing of medicine.

Censorship Kills: The Shunning of a COVID Therapeutic

10/03/2021 No Comments

The science shows that ivermectin works. Over 40 randomized trials and observational studies from around the world attest to its efficacy against the novel coronavirus. Meta-analyses by four separate research groups, including ours, found an average reduction in mortality of between 68%-75%. And 10 of 13 randomized controlled trials found statistically significant reductions in time to viral clearance, an effect not associated with any other COVID-19 therapeutic. Furthermore, ivermectin has an unparalleled safety record and low cost, which should negate any fears or resistance to immediate adoption.

The Chloroquine Wars Part IV

07/03/2021 No Comments

Why then does the pharmaceutical industry and its promoters insist on conducting RCTs before something is accepted as true? RCTs take substantial amounts of time and significant resources to conduct. This creates a barrier to entry, especially for inexpensive solutions to medical problems. In other words, the myth that RCTs are some necessary “gold standard” is a deception that, along with regulatory agency, prevent any possibility for simpler and less expensive (less profitable) medical solutions to gain traction.

The Chloroquine Wars Part III

06/03/2021 No Comments

If the argument rests on “RCTs as the gold standard”, there is little doubt that the evidence dramatically favors using HCQ as a standard early stage therapeutic! But it is reasonable to assess the quality of all the evidence to reach beyond gold for the ultimate and supreme standards of scientific evidence. That too we plan to present in future articles.

‘We think that Ivermectin can help break Covid transmission chains, says Prof Schwartz, Israel

27/02/2021 No Comments

Nobody knows what’s going to happen in the future. Do we have new mutations with more variability? Perhaps the vaccine will be less effective? I think to have an antiviral agent is highly important in so severe a disease. We hope we will not need it in the future. But for now, I think we urgently need and to continue to work on ivermectin.

Act early with early Covid-19 treatment: Dr Vladimir Zelenko

26/02/2021 No Comments

“Dozens of studies being reproduced in several continents show that early treatment within the first five days of observable symptoms, reduces hospitalization in high-risk patients by 84%.

UK: Lice and scabies drug, Ivermectin, could cut Covid deaths by up to 75%, research suggests

25/02/2021 No Comments

More than 30 trials across the world found that ivermectin causes ‘repeated, consistent, large magnitude improvements in clinical outcomes’ at all stages of the disease. The peer-reviewed study, to be published in the US journal Frontiers of Pharmacology, says the evidence is so strong that the drug – used to treat head lice and scabies – should become a standard therapy everywhere, so hastening the global recovery.

Political Hacks At Newsweek Run Anti-Science ‘Fact Check’ On Study Promoting Hydroxychloroquine

24/02/2021 No Comments

In short, Newsweek and the other “fact-checkers” are attempting to arbitrate scientific truth based on their hatred for Donald Trump. These are journalists, not scientists. They have no business misleading the public on the scientific debate over hydroxychloroquine being a preventative treatment for COVID-19.

Ivermectin is effective for COVID-19: real-time meta analysis of 42 studies

23/02/2021 No Comments

Ivermectin is an effective treatment for COVID-19. The probability that an ineffective treatment generated results as positive as the 42 studies to date is estimated to be 1 in 4 trillion (p = 0.00000000000023).

Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study

16/02/2021 No Comments

We conclude that two-dose ivermectin prophylaxis at a dose of 300 μg/kg body weight with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among HCWs in the following one month. Chemoprophylaxis has relevance in the containment of pandemic. This is an intervention worth replicating at other centers until a vaccine is widely available.

Effectiveness of multidrug therapy including ivermectin, to prevent hospitalization and death among ambulatory COVID-19 cases – Mexico

10/02/2021 No Comments

•TNR4 is a multidrug therapy (Ivermectin, Azithromycin, Montelukast and ASA) for COVID-19 cases.

•TNR4 increased the likelihood of recovery 3.4 times in ambulatory COVID-19 cases.

•The multidrug therapy TNR4 reduced the risk of hospitalization by 75%.

•The multidrug therapy TNR4 reduced the risk of death by 81%.

“COVID-19 AND HYDROXYCHLOROQUINE” I DO NOT REGRET ANYTHING “PROFESSOR RAOULT”

08/02/2021 No Comments

The Marseille professor explained himself in an interview with Figaro Magazine on the effectiveness of hydroxychloroquine, conflicts of interest in the scientific community, and the decision taken by Emmanuel Macron not to reconfine.

Emeritus Professor Robert Clancy responds to MP Craig Kelly’s hydroxychloroquine & ivermectin comments: Liam Bartlet‪t‬ interview

04/02/2021 No Comments

Source: 6PR Mornings Australian medical bioscientist and clinical immunologist Robert Clancy, an expert in the relationship between infection and the airways, declares “the data is

Phase 1 Randomized Placebo-Controlled Study in Healthy Adult Volunteers to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate – A Potential Treatment for COVID-19

01/02/2021 No Comments

We tested the hypothesis that aerosolized HCQ sulfate (aHCQ) tolerably, safely, and rapidly achieves high respiratory tissue concentrations, while minimizing systemic toxicity.

HCQ Peer-reviewed: Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection

30/01/2021 No Comments

American Journal of Medicine announces peer-reviewed early outpatient treatment protocol for Covid19 including hydroxychloroquine. Acute COVID-19 has a great range of clinical severity from asymptomatic to fatal. In the absence of clinical trials and guidelines, with hospitalizations and mortality mounting, it is prudent to deploy treatment for COVID-19 based on pathophysiological principles.

Peer-Reviewed Journal Reports Hydroxychloroquine Can Reduce Mortality Rates In COVID-19 Patients

30/01/2021 No Comments

A leading U.S. medical journal announced the medicine hydroxychloroquine can effectively treat the coronavirus.

HCQ and Ivermectin included in multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk COVID-19

28/01/2021 No Comments

Source: AAPS Author: Peter McCullough From the Association of American Physicians and Surgeons: It is our honor to bring Dr. McCullough back to “Doctors Are

Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk COVID-19 infection includes HCQ & Ivermectin

28/01/2021 No Comments

Source: Reviews in Cardiovascular Medicine Peter A. McCullough, Paul E. Alexander, Robin Armstrong, Cristian Arvinte, Alan F. Bain, Richard P. Bartlett, Robert L. Berkowitz, Andrew

Ivermectin for Covid-19: Database of all Ivermectin COVID-19 studies – 35 trials and growing

27/01/2021 No Comments

Source: ivmmeta.com Figure 1. A. Random effects meta-analysis excluding late treatment. Simplified dosages are shown for comparison, these are the total dose in the first two days

The FLCCC Alliance— On a mission to Save Thousands & Slow the Pandemic

20/01/2021 No Comments

The FLCCC Alliance was organized in March, 2020 by a group of highly published, world renowned Critical Care physician/scholars – with the academic support of allied physicians from around the world – to research and develop lifesaving protocols for the prevention and treatment of COVID-19 in all stages of illness.

Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study

14/01/2021 No Comments

In this study of COVID-19, for infected non-hospitalized patients hydroxychloroquine exposure was associated with a decreased rate of subsequent hospitalization

Hydroxychloroquine shows potential to target autoinflammatory component of CPRS

13/01/2021 No Comments

A new Stanford study the first to show that the anti-malarial drug hydroxychloroquine (HCQ) may target the autoinflammatory component of CRPS.

What is Ivermectin? Study shows ‘head lice meds’ cut COVID-19 deaths by 83%

07/01/2021 No Comments

However, analysis concluded that the use of Ivermectin in the management of COVID-19 infections is associated with faster time to viral clearance, shorter duration of hospitalisation, and higher rates of clinical recovery.”

The results of a meta-analysis of 187 studies treating COVID-19 successfully with hydroxychloroquine are statistically irrefutable.

05/01/2021 No Comments

HCQ is effective for COVID-19. The chance that an ineffective treatment generated results as positive as the 187 studies to date is 1 in 5 quadrillion (p = 0.00000000000000019).

Effect of hydroxychloroquine and azithromycin on SARS-CoV-2 clearance in COVID-19 patients, a meta-analysis.

04/01/2021 No Comments

Hydroxychloroquine is an effective molecule against COVID-19 infection, many RCTs and observational studies, affirmed the benefits on virological clearance.

Clinical efficacy and safety profile of hydroxychloroquine and azithromycin against COVID-19

04/01/2021 No Comments

No cases of sudden death were observed. From publication, we have treated 3,119 patients with HCQ-AZ for at least three days.

Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation; the experience from Shanghai, China

18/12/2020 No Comments

The early use of
hydroxychloroquine decreased the improvement time
and the duration of COVID-19 detection in throat and
stool swabs.

Hydroxychloroquine approved in Italy: the full scientific report

16/12/2020 No Comments

This report forms the scientific basis for the decision to authorise hydroxychloroquine in the treatment of Covid-19 in the early phase of the disease.

Yes, hydroxychloroquine is scientifically proven against COVID-19 – PART TWO

15/12/2020 No Comments

Source: Filipe Rafaeli Author: Filipe Rafaeli Read PART ONE here Scientists have already discovered what to do for the hydroxychloroquine to work also in critically

Epidemiologist At Yale Provides Testimony On Hydroxychloroquine For Treating COVID-19

14/12/2020 No Comments

Source: Collective Evolution Author: Arjun Walia IN BRIEF The Facts: Dr. Harvey Risch, MD, Ph.D., Yale Professor of Epidemiology and Public Health provides evidence-based testimony

A massive hydroxychloroquine meta-analysis (156 studies) has just been updated (version 28!).It says that HCQ works beyond all statistical doubt.

05/12/2020 No Comments

Source: HCQMeta.com HCQ is effective for COVID-19 when used early: meta-analysis of 156 studies (Version 28, December 4, 2020) • HCQ is effective for COVID-19.

Effective post-exposure prophylaxis of Covid-19 is associated with use of HCQ: Prospective re-analysis of a public dataset incorporating novel data

02/12/2020 No Comments

Source: MedRxIV David M. Wiseman, Pierre Kory, Samir A Saidi, Dan Mazzucco doi: https://doi.org/10.1101/2020.11.29.20235218 Abstract BACKGROUND A recent trial (NCT04308668) found that post-exposure prophylaxis with hydroxychloroquine (HCQ) was associated with a reduced incidence

Chloroquine / hydroxychloroquine could treat COVID-19 infection

01/12/2020 No Comments

Chloroquine / hydroxychloroquine could treat COVID-19 infection

Peer-reviewed hydroxychloroquine study finds 84% fewer hospitalizations among early treated outpatients

24/11/2020 No Comments

Source: The Blaze Author: CHRIS PANDOLFO A peer-reviewed study analyzing the effectiveness of a triple drug cocktail including hydroxychloroquine in treating COVID-19 patients found that the treatment

In 2003, the effects of chloroquine/HCQ on viral infections were known: an old drug pitted against SARS and HIV

14/11/2020 No Comments

Results obtained in the prophylaxis of Q fever indicate that chloroquine/hydroxychloroquine can be successfully used in the clinical management of infections other than malaria.

Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March–June 2020

13/11/2020 No Comments

Source: Science Direct Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michael Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse,

Prevalence of Diabetes, Management and Outcomes among Covid-19 Patients; HCQ protects from Covid-19 death by 88%: Saudi Arabia

13/11/2020 No Comments

Source: Science Direct Eman Sheshah, Shaun Sabico, Rashed M. Albakr, Anmar A. Sultan, Khalaf S. Alghamdi, Khaled Al Madani, Hadil A. Alotair, Nasser M. Al-Daghri,Prevalence

Hydroxychloroquine for prophylaxis and treatment of COVID-19 in health care workers: Bulgaria

12/11/2020 No Comments

Source: Science Direct Simova I, Vekov T, Krasnaliev J, Kornovski V, Bozhinov P,Hydroxychloroquine for prophylaxis and treatment of COVID-19 in health care workers, New Microbesand

Study: Anti-Malarial Drug HCQ Helps Outpatients With COVID-19

11/11/2020 No Comments

Source: News Max Author: By Brian Trusdell Photo: Getty The anti-malarial drug promoted by the US President as a treatment for COVID-19 — and derided by

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