Hydroxychloroquine official statements, trials and studies

06/04/2021

Clinical outcomes of patients with mild COVID-19 following treatment with hydroxychloroquine in an outpatient setting

Our investigation of a large national cohort appears to support early administration (within the first 3 to 7 days of COVID-19 diagnosis) of HCQ in mild COVID-19 disease in an outpatient setting for reducing hospitalizations and deaths without any serious adverse HCQ-related effects.
If this finding is confirmed in future clinical trials, HCQ as a cheap and available drug may still play a role in a specific population with respect to reducing COVID-19 burden, particularly in resource-poor countries.

06/04/2021

17/03/2021

Structural basis of anti-SARS-CoV-2 activity of hydroxychloroquine: specific binding to NTD/CTD and disruption of LLPS of N protein

In this study, by use of DIC microscopy and NMR spectroscopy, for the first time we have decoded that HCQ specifically binds to both N-terminal domain (NTD) and C-terminal domain (CTD) of SARS-CoV-2 nucleocapsid (N) protein to inhibit their interactions with nucleic acids (NAs), as well as to disrupt its NA-induced liquid-liquid phase separation (LLPS) essential for the viral life cycle including the package of gRNA and N protein into new virions.

17/03/2021

10/02/2021

Letter to NEJM queries excessive doses of hydroxychloroquine in Covid-19 ‘Recovery’ trial

The dose used in the RECOVERY trial, arouses concern because it may have been a disease-aggravating factor negating the therapeutic effect.

10/02/2021

01/02/2021

Phase 1 Randomized Placebo-Controlled Study in Healthy Adult Volunteers to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate – A Potential Treatment for COVID-19

We tested the hypothesis that aerosolized HCQ sulfate (aHCQ) tolerably, safely, and rapidly achieves high respiratory tissue concentrations, while minimizing systemic toxicity.

01/02/2021

30/01/2021

HCQ Peer-reviewed: Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection

American Journal of Medicine announces peer-reviewed early outpatient treatment protocol for Covid19 including hydroxychloroquine. Acute COVID-19 has a great range of clinical severity from asymptomatic to fatal. In the absence of clinical trials and guidelines, with hospitalizations and mortality mounting, it is prudent to deploy treatment for COVID-19 based on pathophysiological principles.

30/01/2021

28/01/2021

Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk COVID-19 infection includes HCQ & Ivermectin

Source: Reviews in Cardiovascular Medicine Peter A. McCullough, Paul E. Alexander, Robin Armstrong, Cristian Arvinte, Alan F. Bain, Richard P. Bartlett, Robert L. Berkowitz, Andrew …

28/01/2021

14/01/2021

Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study

In this study of COVID-19, for infected non-hospitalized patients hydroxychloroquine exposure was associated with a decreased rate of subsequent hospitalization

14/01/2021

07/01/2021

High Hydroxychloroquine Blood Level May Lower Thrombosis Risk in Lupus

Maintaining an average hydroxychloroquine whole blood level above 1,068 ng/mL significantly reduced the risk of thrombosis in adults with systemic lupus.

07/01/2021

05/01/2021

Higher Hydroxychloroquine Blood Levels Are Associated with Reduced Thrombosis Risk in Systemic Lupus Erythematosus

Source: PubMed Petri M, Konig MF, Li J, Goldman DW. Higher Hydroxychloroquine Blood Levels Are Associated with Reduced Thrombosis Risk in Systemic Lupus Erythematosus. Arthritis …

05/01/2021

04/01/2021

Effect of hydroxychloroquine and azithromycin on SARS-CoV-2 clearance in COVID-19 patients, a meta-analysis.

Hydroxychloroquine is an effective molecule against COVID-19 infection, many RCTs and observational studies, affirmed the benefits on virological clearance.

04/01/2021

04/01/2021

Clinical efficacy and safety profile of hydroxychloroquine and azithromycin against COVID-19

No cases of sudden death were observed. From publication, we have treated 3,119 patients with HCQ-AZ for at least three days.

04/01/2021

30/12/2020

Top US medics recommend ‘sequenced multidrug therapy’ including HCQ & Ivermectin, for early high-risk COVID-19 infections

Early SMDT (sequenced multidrug therapy) should be a standard practice in high risk & severely symptomatic acute COVID-19 patients at the onset of illness.

30/12/2020

28/12/2020

BENGAL’S MANAGEMENT PROTOCOL FOR COVID-19 INCLUDES HCQ

Bengal has released this document to state their COVID-19 policies, which include the use of HCQ. Well done Bengal.

28/12/2020

18/12/2020

Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation; the experience from Shanghai, China

The early use of
hydroxychloroquine decreased the improvement time
and the duration of COVID-19 detection in throat and
stool swabs.

18/12/2020

15/12/2020

TGA banned a functioning treatment & Australian doctors want answers – Urgent request for revocation of HCQ ban

Adjunct Prof John SkerrittDeputy SecretaryHealth Products Regulation GroupJohn.Skerritt@health.gov.auGPO Box 9848, Canberra, ACT Dear Professor Skerritt,We are writing to express our concerns regarding the role of …

15/12/2020

05/12/2020

A massive hydroxychloroquine meta-analysis (156 studies) has just been updated (version 28!).It says that HCQ works beyond all statistical doubt.

Source: HCQMeta.com HCQ is effective for COVID-19 when used early: meta-analysis of 156 studies (Version 28, December 4, 2020) • HCQ is effective for COVID-19. …

05/12/2020

02/12/2020

Low Dose Hydroxychloroquine is Associated with Lower Mortality in COVID-19: A Meta-Analysis of 27 Studies and 44,684 Patients

Source: Research Square. Methods This study was conducted according to the recommendations outlined in the Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0, and …

02/12/2020

16/11/2020

Swiss Policy Research on the Treatment of Covid-19

Source: swprs.org On the Treatment of Covid-19 Updated: November 16, 2020; Published: July 2, 2020 Immunological and serological studies show that most people develop only mild …

16/11/2020

14/11/2020

In 2003, the effects of chloroquine/HCQ on viral infections were known: an old drug pitted against SARS and HIV

Results obtained in the prophylaxis of Q fever indicate that chloroquine/hydroxychloroquine can be successfully used in the clinical management of infections other than malaria.

14/11/2020

13/11/2020

Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March–June 2020

Source: Science Direct Tran Duc Anh Ly, Didier Zanini, Vincent Laforge, Sylvie Arlotto, Stephanie Gentile, Helene Mendizabal, Michael Finaud, David Morel, Olivier Quenette, Priscilla Malfuson-Clot-Faybesse, …

13/11/2020

13/11/2020

Prevalence of Diabetes, Management and Outcomes among Covid-19 Patients; HCQ protects from Covid-19 death by 88%: Saudi Arabia

Source: Science Direct Eman Sheshah, Shaun Sabico, Rashed M. Albakr, Anmar A. Sultan, Khalaf S. Alghamdi, Khaled Al Madani, Hadil A. Alotair, Nasser M. Al-Daghri,Prevalence …

13/11/2020

12/11/2020

Hydroxychloroquine for prophylaxis and treatment of COVID-19 in health care workers: Bulgaria

Source: Science Direct Simova I, Vekov T, Krasnaliev J, Kornovski V, Bozhinov P,Hydroxychloroquine for prophylaxis and treatment of COVID-19 in health care workers, New Microbesand …

12/11/2020

06/11/2020

Hydroxychloroquine Not Linked to Longer Heart Rhythm Intervals in Rheumatoid Arthritis or Lupus Patients

Of the whole study group (RA and SLE), 54% used hydroxychloroquine and 44% had QTc lengths of more than 440 milliseconds. They found that the adjusted QTc length among hydroxychloroquine users was comparable to those who did not use the drug.

06/11/2020

06/11/2020

Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A single-center experience

Source: Journal of Marine Medical Society Date of Submission 23-Aug-2020 Date of Decision 18-Sep-2020 Date of Acceptance 29-Sep-2020 Date of Web Publication 06-Nov-2020 Correspondence Address:Vivek …

06/11/2020

06/11/2020

India: Post Exposure Prophylaxis with Hydroxychloroquine (HCQ) for the Prevention of COVID-19, a Myth or a Reality? The PEP-CQ Study

Source: Science Direct Dr. Deba PrasadDhibarMD(Assistant Professor)aDr. NavneetAroraMD(Senior Resident)aDr. ArpitKakkarDNB(Senior Resident)aDr. NeerajSinglaMD(Assistant Professor)bDr. RitinMohindraMD(Assistant Professor)bDr. VikasSuriMD(Additional Professor)bDr. AshishBhallaMD(Professor)bDr. NavneetSharmaMD(Professor)bDr. Mini PSinghMD(Professor)cDr. AjayPrakashPhd(Assistant Professor)dDr. LakshmiPVMMD(Professor)eDr. BikashMedhiMD(Professor)d …

06/11/2020

03/11/2020

Doc Who Used Hydroxychloroquine Met Standard of Care, Says Med Board; More

The TMB stated that there was insufficient evidence to prove that a violation of the Medical Practice Act [had] occurred when reviewing Dr Urso

03/11/2020

03/11/2020

Inhalable liposomal hydroxychloroquine (TLC19) may provide clinical benefit and serve as a potential treatment for COVID-19: Taiwan & California

Source: BioSpace SOUTH SAN FRANCISCO, Calif. and TAIPEI, Taiwan, Nov. 03, 2020 (GLOBE NEWSWIRE) — TLC (Nasdaq: TLC, TWO: 4152), a clinical-stage specialty pharmaceutical company developing novel …

03/11/2020

02/11/2020

HCQ is effective for COVID-19 when used early: analysis of 132 studies

Source: HCQmeta.com • HCQ is effective for COVID-19. The probability that an ineffective treatment generated results as positive as the 132 studies to date is …

02/11/2020

26/10/2020

Clinical Characteristics and Prognosis of COPD Patients Hospitalized with SARS-CoV-2

We found a higher survival rate in patients treated with hydroxychloroquine and with macrolides in our study.

26/10/2020

23/10/2020

HCQ is effective for COVID-19 when used early: analysis of 118 studies

HCQ is effective for COVID-19. The probability that an ineffective treatment generated results as positive as the 115 studies to date is estimated to be 1 in 20 million (p = 0.000000049).

23/10/2020

21/10/2020

Outcomes of patients with COVID-19 in the Intensive Care Unit in Mexico: A multicenter observational study

This study of critically ill patients with laboratory-confirmed COVID-19 admitted to ICUs in Mexico demonstrated that age and CRP levels upon ICU admission were associated with in-hospital mortality

21/10/2020

18/10/2020

Crimes Against Humanity / Mass Murder

This petition must be signed so as those responsible for the murder of countless lives can be brought to justice.

18/10/2020

17/10/2020

Hydroxychloroquine Safety Outcome within Approved Therapeutic Protocol for COVID-19 Outpatients in Saudi Arabia

Our results can assure that hydroxychloroquine used for COVID-19 patients is safe, highly tolerable, and with minimum side effects.

17/10/2020

15/10/2020

Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials, glucocorticoids, or immunomodulation with tocilizumab or cyclosporine: A retrospective observational study (COQUIMA cohort)

The aim of this study is to describe the characteristics and impact of different therapies on clinical outcomes in a cohort of severe COVID-19 patients.

15/10/2020

01/10/2020

Saudi Arabia – Comparing the impact of Hydroxychloroquine based regimens and standard treatment on COVID-19 patient outcomes: A retrospective cohort study

Hydroxychloroquine had a modest effect on hospital length stay and days in ICU compared with Standard Care.

01/10/2020

30/09/2020

Hydroxychloroquine Use on Healthcare Workers Exposed to COVID-19 – A Pandemic Hospital Experience;Turkey

Our findings indicate that Hydroxychloroquine can be an effective agent in postexposure prophylaxis.

30/09/2020

29/09/2020

Spain/US – Brief communication: A meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19 (HCQ reduces the risk of COVID-19 by about 20%)

Source: MedRxiv. Full Study in PDF here Xabier Garcia-Albeniz, Julia Del Amo, Rosa Polo, Jose Miguel Morales Asencio, Miguel A HernanmedRxiv 2020.09.29.20203869; doi: https://doi.org/10.1101/2020.09.29.20203869 Abstract Background: There is disagreement about whether hydroxychloroquine (HCQ) is effective as prophylaxis …

29/09/2020

28/09/2020

C19study.com update: Now 118 international studies (71 peer reviewed) show positive hydroxychloroquine treatment outcomes

Source: C19Study A live and ongoing index of studies from around the world documenting the use of hydroxychloroquine in treatment at various stages of SARS-CoV-2 infection …

28/09/2020

28/09/2020

Italy study: A new look at safety with hydroxychloroquine in COVID-19

In our study, we found hydroxychloroquine wasn’t associated with significant arrhythmia clearly relating to hydroxychloroquine so it seemed the drug was very, very safe

28/09/2020

25/09/2020

Hydroxychloroquine seems to be safe for COVID-19 patients, report researchers focused on arrhythmic safety

Hydroxychloroquine seems to be safe, regardless of the clinical setting in which it is started, so long as an adequate ECG monitoring strategy is in place.

25/09/2020

22/09/2020

Saudi Arabia – Therapeutic Management of Coronavirus Disease 2019 (COVID-19): A Systematic Review and Treatment Algorithm

Therefore, Hydroxychloroquine is considered as the first‐line of COVID-19 treatment.

22/09/2020

22/09/2020

US: Hydroxychloroquine and Interferons for the Prophylaxis and Early Treatment of Covid-19-Current Clinical Advances (shows benefit)

Source: Longdom.org ABSTRACT Coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) calls for unprecedented measures to control the spread …

22/09/2020

22/09/2020

Hydroxychloroquine and Interferons for the Prophylaxis and Early Treatment of Covid-19-Current Clinical Advances

These results are evidences to support the early use of HCQ in post exposure prophylaxis.

22/09/2020

21/09/2020

The Treatment of Viral Diseases: Has the Truth Been Suppressed for Decades?

To have covered up the knowledge for four decades that viruses could potentially be treated by antimicrobials required extensive effort

21/09/2020

21/09/2020

Lancet: “Overall mortality was lower in the hydroxychloroquine group”. Study, Long-term hydroxychloroquine use in patients with rheumatic conditions and development of SARS-CoV-2 infection: a retrospective cohort study

Source: The Lancet Summary Background Hydroxychloroquine is one of several agents being evaluated in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …

21/09/2020

21/09/2020

University of Minnesota study: “No deaths occurred related to hydroxychloroquine. ” Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19

In this trial, no deaths occurred related to hydroxychloroquine, and serious side effects were rare.

21/09/2020

21/09/2020

Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19

Source: MedRxiv  View ORCID ProfileSARAH M LOFGREN,  View ORCID ProfileMelanie R Nicol, Ananta S Bangdiwala,  View ORCID ProfileKatelyn A Pastick,  View ORCID ProfileElizabeth C Okafor,  View ORCID ProfileCaleb P Skipper,  View ORCID ProfileMatthew F Pullen,  View ORCID ProfileNicole W Engen,  View …

21/09/2020

20/09/2020

HYDROXYCHLOROQUINE AND THE BURDEN OF PROOF

An Urgent Call to Depoliticize Medicine in the COVID-19 Pandemic

20/09/2020

17/09/2020

7th U.S. state, Nevada, quietly reverses it’s hydroxychloroquine ban for COVID-19

Source: Dr Simone Gold Frontline Doctors’ Dr Simone Gold tweets: Nevada is now the 7th state to quietly reverse their decision to block HCQ prescriptions for …

17/09/2020

16/09/2020

Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations

Source: Taylor & Francis Online Eleni Karatza, George Ismailos, Markos Marangos & Vangelis Karalis (2020) Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review …

16/09/2020

15/09/2020

Clinical characteristics, treatment regimen and duration of hospitalization among COVID-19 patients in Ghana: a retrospective cohort study

Source: Pan African Medical Journal Mary Eyram Ashinyo1,&, Vida Duti2, Stephen Dajaan Dubik3, Kingsley Ebenezer Amegah4, Selorm Kutsoati5, Ebenezer Oduro-Mensah6, Peter Puplampu7, Martha Gyansa-Lutterodt8, Delese …

15/09/2020

14/09/2020

Effect of combination therapy of hydroxychloroquine and azithromycin on mortality in COVID‐19 patients.

Source: Clinical & Translational Science Marinella Lauriola Arianna Pani Giovanbattista IppolitiAndrea MortaraStefano MilighettiMarjieh MazenGianluca PerseghinDaniele PastoriPaolo GrossoFrancesco Scaglione doi:10.1111/cts.12860 Full study here. Abstract Conflicting evidence …

14/09/2020

13/09/2020

The Effect of Early Hydroxychloroquine-based Therapy in COVID-19 Patients in Ambulatory Care Settings: A Nationwide Prospective Cohort Study

Source: MedRxiv Tarek Sulaiman,  View ORCID ProfileAbdulrhman Mohana, Laila Alawdah, Nagla Mahmoud, Mustafa Hassanein, Tariq Wani, Amel Alfaifi, Eissa Alenazi, Nashwa Radwan, Nasser AlKhalifah, Ehab Elkady, Manwer AlAnazi, Mohammed Alqahtani, Khalid Abdalla, Yousif Yousif, Fouad AboGazalah, Fuad Awwad, Khaled AlabdulKareem, Fahad AlGhofaili, Ahmed AlJedai, Hani Jokhdar, Fahad Alrabiah doi: https://doi.org/10.1101/2020.09.09.20184143 Abstract ABSTRACT BACKGROUND: Currently, there is no proven effective therapy nor vaccine for the treatment of SARS-CoV-2. Evidence regarding …

13/09/2020

08/09/2020

Hydroxychloroquine Reduces Risk Of Death From COVID-19 By 30%, Latest Italian Study Shows

Source: The Gateway Pundit Author: Eric A. Blair An Italian study finds that hydroxychloroquine substantially reduces the risk of death for COVID-19 patients. “We observed …

08/09/2020

07/09/2020

France: Natural history of COVID-19 and therapeutic options (hydroxychloroquine, azithromycin and zinc may represent the best current theraputic option)

‘’Treatment with an oral combination of hydroxychloroquine, azithromycin and zinc may REPRESENT THE BEST CURRENT THERAPEUTIC OPTION in relation to its antiviral and immunomodulatory effects’’.

07/09/2020

07/09/2020

Analysis of the predictive factors for critical illness of COVID-19 during treatment – Relationship between serum zinc level and critical illness of COVID-19

Source: Science Direct Author links YukakoYasuiaHiroyukiYasuibKumikoSuzukicTakakoSaitoucYoshikiYamamotoaToshihikoIshizakaaKoujiNishidadShingoYoshiharaeIwaoGohmadYoshihikoOgawae aDepartment of Pharmacy, Sakai City Medical Center, 1-1-1 Ebaraji-cho, Nishi-ku, Sakai City, Osaka, 593-8304, Japan bDepartment of Analytical & …

07/09/2020

06/09/2020

C19study.com update: Now 88 international studies (51 peer reviewed) show positive hydroxychloroquine treatment outcomes

Source: c19 Study A live and ongoing index of study data from around the world documenting the use of hydroxychloroquine in treatment at various stages …

06/09/2020

04/09/2020

Hydroxychloroquine is Effective and Safe for the Treatment of COVID-19, and May be Universally Effective When Used Early Before Hospitalization: A Systematic Review

Source: Research Gate Conclusions Hydroxychloroquine has been shown to have consistent clinical efficacy for COVID-19 when it is used early in the outpatient setting, and …

04/09/2020

03/09/2020

Indian Medical Association endorses prophylactic HCQ use for police force

Source: Steven Phillips, MD Indian Medical Association endorses prophylactic use of HCQ for the police department to prevent COVID19. The Bengal State Branch recommended to …

03/09/2020

02/09/2020

COVID-19 mortality risk factors in older people in a long-term care center

It could be possible that this treatment only works when used early and in particular patient groups with similar characteristics as in the present study.

02/09/2020