The anti-HIV effect of chloroquine/hydroxychloroquine is modest by itself but is additive or synergistic when combined with selected antiretrovirals.
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Source: NIH Savarino A, Boelaert JR, Cassone A, Majori G, Cauda R. Effects of chloroquine on viral infections: an old drug against today’s diseases?. Lancet Infect Dis. 2003;3(11):722‐727. doi:10.1016/s1473-3099(03)00806-5 Abstract Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral […]
Source: PubMed.com Abstract Exposure of influenza B virus-infected MDCK cells to chloroquine at the time of infection resulted in significant inhibition of infection. The appearance of input virus in the intracellular vesicles was not affected in the presence of the drug, but primary transcription of the virus genome did not occur. Chloroquine caused a rapid […]