Source: PubMed. Author: Jean-Michel Scherrmann

Scherrmann JM. Possible role of ABCB1 in lysosomal accumulation of azithromycin in COVID-19 therapy [published online ahead of print, 2020 Aug 17]. Clin Pharmacol Ther. 2020;10.1002/cpt.2020. doi:10.1002/cpt.2020


The antiviral use of azithromycin in COVID-19 was recently reported by Damle et al. Its combination with hydroxychloroquine did not aim at preventing bacterial super-infection as often believed, but at benefiting from their common lysosomotropic properties which buffer the acidic conditions (pH 4-5) of the endolysosomal lumen where SARS-CoV-2 transits following its ACE-2 receptor-mediated endocytosis. These two powerful cationic and amphiphilic drugs increase up to neutrality the intravesicular pH causing disorders in lysosomal functions such as enzyme inhibitions involved in the virus replication cycle. We recently hypothesized that the ATP-binding cassette ABCB1 (P-glycoprotein) could be involved in this reported synergistic effect.

Related: The effect of 5-day course of hydroxychloroquine and azithromycin combination on QT interval in non-ICU COVID19(+) patients

Harvey Risch, Yale School of Medicine “The Key to Defeating COVID-19 Already Exists. We Need to Start Using It

The Epoch Times – Adam Carolla: Why Does the Media Shun Hydroxychloroquine?

Algeria: 90% of cases have responded very well to this treatment protocol – HCQ proves effective

Share on facebook
Share on twitter
Share on whatsapp
On Trend

Latest Stories

A Conversation With Dr. Brian Tyson – The Chloroquine Wars Part XLI

The data from the vaccine trials must be recalculated under the lens that some of the serious adverse events (SAEs) should be treated as COVID-19 cases.
There may not be any vaccine efficacy in the data at all if some of the post-vaccination deaths are due to vaccine-induced COVID-19. It could even be the case that the mortality efficacy goes negative. My implied lives saved calculations put this easily in the realm of possibility. The only way to know is for authorities to organize and compile the data. And while a risk analysis is certainly due after more than six months of hundreds of millions of doses delivered, there is little indication authorities have bothered with the process. That’s more than a bit unsettling.

Read More »

Dr. Brian Tyson, USA: Hydroxychloroquine – Data, Strategies and Success Treating over 6000 Covid Patients

We continue to delve extensively into the COVID-19 data with esteemed statistician, Mathew Crawford. In this episode, we take a closer look at the use of early treatment and its success. Mathew has been researching the data from Dr. Brian Tyson, who has successfully treated over 6000 patients who contracted COVID throughout the pandemic. It is my great honor to have Dr. Tyson here on this episode to not only discuss the data, but also the strategies that he has been using throughout the pandemic.

Read More »