Source: RheumNow

A lupus cohort study from British Columbia, Canada has shown that medication adherence with hydroxychloroquine (HCQ) is associated with a 71% to 83% lower mortality. 

Researchers identified all incident SLE cases taking antimalarials (AM) from provincial administrative databases between 1997 adn 2015 to examine all‐cause mortality and its relationship with medication adherence. Adherence was measured as the proportion of days covered (PDC), with those adherent having a PDC≥0.90, and the non‐adherent having a PDC<0.90), compared with those who discontinued (PDC=0) during a 30‐day window.

We identified 3,062 incident SLE patients on antimalarials (mean age 46.9 years). Death was observed in 242 (7.9%) after a mean follow‐up of 6.4 years.

Compared with those who discontinued therapy, mortality was lower for AM adherent (adjusted hazard ratio [aHR] 0.20; 95% CI:0.13‐0.29) and non‐adherent SLE patients (aHR 0.62; 95% CI:0.42‐0.91).  A significant trend in the aHRs of mortality risk over the adherence levels was found (p‐value:<0.001).

Chronic adherence to antimalarial therapy in SLE resulted in a 71% and 83% lower risk of death. This critically important, given the data showing that 40-50% of SLE patients are noncompliant with hydroxychloroquine. 

CONTINUE READINGImpact of Antimalarial Adherence on Mortality among Patients with Newly Diagnosed Systemic Lupus Erythematosus: A Population‐based Cohort Study






Related:

Coronavirus and hydroxychloroquine. A cure that works, but that is not authorized …

Piedmont gives the green light to hydroxychloroquine

Ruling gives green light for controversial COVID-19 therapy

Council of State: yes to the use of hydroxychloroquine for the treatment of Covid:

Share on facebook
Share on twitter
Share on whatsapp
On Trend

Latest Stories

Stark madness to ban ivermectin

Buried in the note is the real reason for making ivermectin inaccessible – the fear that persons taking it ‘may elect not to be vaccinated as part of the national Covid-19 vaccination program’. This is outrageous. When someone is infected with Covid, it is too late to bother with vaccination. They need early treatment. To deny it to coerce them into accepting a vaccine, one of whose side-effects is death, is immoral.

Read More »

Australia’s TGA Bans GPs from Prescribing Ivermectin

Australia’s medicine and therapeutic regulatory, the Therapeutic Good Administration (TGA) recently took the gloves off with Ivermectin, the economical anti-parasitic drug associated with at least 63 completed clinical trials involving SARS-CoV-2, the virus behind COVID-19. Now TGA formally places a national prohibition on off-label prescribing of ivermectin to all general practitioners. A comparable move as to what TGA did with hydroxychloroquine in 2020. Clearly further evidence of tightening encroachment of the critically important doctor-patient treatment relationship allowing consent to medical treatment using off-label medications. Of course, this isn’t occurring in a vacuum—it’s part of an unfolding, integrated and what have the signs of a coordinated and orchestrated government action to stop any and all treatments other than those the government declares acceptable.

Read More »